Gary S. Stein
|Chair of the Department of BiochemistryCo-director, Vermont Cancer Center for Basic and Translational Research|
|O: HSRF 326||L: HSRF 315|
|O: 802-656-6613||L: 802-656-3493|
Gene Expression & Regulation
Signal Transduction & Cell Signaling
Gary S. Stein, PhD, is the Professor and Chair of the Department of Biochemistry at the University of Vermont (UVM) and Co-Director of the UVM Cancer Center. The central theme of Gary Stein’s research has been to discover mechanisms controlling proliferation and differentiation with emphasis on compromised regulation that is linked with disease. From the earliest stages of his career, he has pioneered characterization of transcriptional regulation that mediates cell cycle control. His studies have provided considerable insight into the molecular mechanisms regulating gene expression during the cell cycle at the G1/S phase transition in normal and tumor cells. He has characterized the unique parameters of cell cycle control that govern proliferation in human embryonic stem cells and reprogrammed pluripotent cells. The second field in which Gary Stein has had major and lasting impact is skeletal biology, where he established the foundation for addressing bone tissue specific gene expression, and provided valuable insight into aberrations that accompany the onset and progression of skeletal disease and tumor metastasis to bone. Furthermore, he has been instrumental in defining functional relationships between the nuclear organization of regulatory networks and gene expression that are mediated by transcription factors, coregulatory proteins and microRNAs. He has made seminal contributions to mechanisms that support combinatorial organization and assembly of regulatory machinery for gene expression in nuclear microenvironments and epigenetic control of cell fate and lineage commitment in biological control and cancer.
Gary Stein has published more than 800 papers in leading biomedical journals and edited more than 15 books. “Human Stem Cell Technology and Biology: A Research Guide and Laboratory Manual” was recently published by Wiley-Blackwell. This book comprehensively presents the biology of stem cells, the laboratory skills required for stem cell investigation and insight into the potential application of stem cells for treating diseases that are not responsive to conventional therapies.
Gary Stein has organized and chaired numerous international research conferences, and serves on advisory panels for United States and foreign government science policy and granting agencies, scientific advisory boards for biotechnology, pharmaceutical and health care organizations, and editorial boards of more than 16 journals. Throughout his career he has been committed to providing mentorship to more than 100 graduate students, postdoctoral students, and physician/scientists, developing research and science education programs in his institution as well as with universities in Europe, Asia, the Middle East and South America.
Dr. Stein directs a research program of 45 basic scientists and physician/investigators who are dedicated to discovering aberrant regulatory mechanisms in cancer cells and developing new dimensions to cancer diagnosis and therapy. His research program is sponsored by the National Cancer Institute and by research foundations. He is principal investigator of two program project grants and several R01 grants from the National Institutes of Health.