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Kenneth Mann, Ph.D.
Professor
Kenneth.Mann@uvm.edu
O: CRFT227C L:
O: 802-656-0335 L:

Research Interests:
Cardiovascular Biology & Disease
Physical Biochemistry
Proteomic & Metabolism

Background:
Dr. Mann received his Ph.D. in Biochemistry (C.S. Vestling) at the University of Iowa. After additional post- doctoral training in physical biochemistry at Duke University (C. Tanford), he moved to the University of Minnesota as an Assistant Professor. His interest in applying Physical Biochemistry techniques to elucidating the varied physical and functional interactions of proteins in the blood coagulation process was encouraged by a joint appointment at the Mayo Clinic (Mayo Medical School), where he achieved the rank of Professor of Biochemistry and Medicine and became Vice Chair of the Department of Medicine. He came to UVM in 1984 as Professor and Chair of Biochemistry, and he relinquished the Chair in 2005. Dr. Mann has received many National and international awards, including the E. Donnall Thomas Award (ASH), the Sherry Award (AHA) and the Wood Medal (ISTH).

 

Project Description:
Our laboratory is interested in the superamolecular organization of protein-ligand complex assemblies and the functional expression of these assemblies. The principal physiologic model we examine is the process of blood coagulation. Studies extend from biophysical analyses of the assembly of the multi-protein complexes involved in the formation of blood coagulation catalysts to physiologic studies of congenital and acquired thrombotic and hemorragic diseases. These latter studies extend from computer models to human physiology in the expression and regulation of coagulation reactions. Studies of normal and pathologic human blood coagulation make use of a multifaceted array of analytical procedures to evaluate product precursor relationships during the coagulation process. Ultimately our research is aimed at developing better procedures for the diagnosis and therapeutic intervention in hemorragic and thrombotic diseases which are based upon mechanistically sound chemical descriptions of these processes.

 
Selected Publications:

Undas A, Brummel-Ziedins KE and Mann KG: Antithrombotic properties of aspirin and resistance to aspirin: beyond strictly antiplatelet actions. Blood. In press, March 2007.

Mann KG, Brummel-Ziedins KE, Orfeo T and Butenas S: Models of blood coagulation. Blood Cells, Molecules & Diseases, 36:108-117, 2006.

Undas A, Brummel-Ziedins K and Mann KG: Statins and Blood Coagulation. Aterioscler. Thromb. Vasc. Biol. 25(2):287-94, 2005.

Orfeo T, Butenas S, Brummel-Ziedins KE, Mann KG: The tissue factor requirement in blood coagulation. J. Biol. Chem. 280:42887-42896, 2005.

Brummel-Ziedins KE, Vossen CY, Butenas S, Mann KG and Rosendaal FR: Thrombin generation profiles in deep venous thrombosis. J. Thromb. Haemost. 3:2497-2505, 2005.

Orfeo T, Brufatto N, Nesheim ME, Xu H, Butenas S and Mann KG: The factor V activation paradox. J. Biol. Chem. 279:19580-19591, 2004.

Mann KG: Thrombin Can’t Live Without It; Probably Die From It. CHEST 2003; 124:1S-3S.

Mann KG, Butenas S and Brummel K: The Dynamics of Thrombin Formation. Arteroscler. Thromb. Vasc. Biol. 23:17-25, 2003.

Mann KG and Kalafatis M: Factor V: a combination of Dr. Jekyll and Mr. Hyde. Blood, 1-1: 1-11 2003.

All Mann publications