From the Brummel-Ziedins Laboratory
Her area of research interest is in addressing questions of hemostasis, hemorrhage and thrombosis in normal and disease states using a multidisciplinary approach. Her focus has been in the use of a whole blood model, which attempts to mimic in vivo situations, and the use of a numerical simulation model that allows her to investigate the tissue factor pathway of coagulation at concentrations that are not measured by current technology in large populations. She studies the enzymatic events leading up to and following clot formation and how they alter in various disease states. With the combination of these systems, she have been developing protein profiles of “normal/healthy” individuals and individuals with hemorrhage and thrombosis. Her hope is to be able to develop markers of coagulation, which can include thrombin generation and fibrin generation/degradation, as potential predictors of individualized phenotype in the maintenance of hemostasis. As well as to aid in the treatment of individuals that are suffering from bleeding or clotting disorders.